| Sensorium AG | |
| Sensors.ch | Neuchâtel |
| Sensoryx AG | |
| SEOJuice | |
| Seologen | |
| Sercon ICT-Services | Zurich |
| Sertek AG | Aargau |
| Service Projects Profile | Solothurn |
| Services-Entrepreneurs | Vaud |
| SES AG | Lucerne |
| Sesamnet | Fribourg |
| session.vc AG | |
| Seven94.net AG | Bern |
| Sevense Robotics AG | |
| Sevensense Robotics AG | |
| sevenskills GmbH | Zurich |
| Sevitec | Thurgau |
| Seyonic S.A. | |
| SFL Regulatory Affairs & Scientific Communication GmbH | |
| SGDL Innovation S.A. | |
| SGS Société Générale de Surveillance S.A. | |
| Share out | |
| Sharp Electronics (Schweiz) AG | Zurich |
| Sherpany | Zurich |
| Shift Cryptosecurity AG | Zurich |
| SHL Medical AG | |
| shop-24.cc GmbH | Bern |
| SIBEX AG | |
| Sidata AG | Thurgau |
| Siegfried Holding AG | |
| Signalhorn AG | Valais |
| Sigrist Marketing-Services | Zurich |
| Sika AG | |
| Sileno AG | Schaffhausen |
| Silony Medical GmbH | |
| SIMORE | Vaud |
| Simpex Electronic AG | Zurich |
| Simply-More.ch | Solothurn |
| Simtec AG | Basel-Landschaft |
| Sintetica S.A. | |
| Sitepoint GmbH | Bern |
| Siteware Systems GmbH | Zurich |
| Siteweb.ch S.à.r.l. | Neuchâtel |
| SIX Digital Exchange | Zurich |
| sixa AG | |
| SixPeaks Bio AG | |
| SixSq S.à.r.l. | Geneva |
| Sketchin | |
| SkillSonics International AG | |
| SKR Consulting S.A. | |