| Skribble AG | |
| SkyCell AG | |
| Sleepiz AG | |
| Sly AG | |
| SM Service Marketing AG | Lucerne |
| Smallpdf Ltd | |
| Smart Valor | |
| SmartCall | Schwyz |
| SmartCredit.io | |
| Smartec | Ticino |
| Smartec Services AG | Zug |
| Smartfactory AG | |
| SmartHelio | Vaud |
| Smartlink S.A. | |
| SmartMoneyMatch | |
| SmartScout | |
| SmartWall | Zurich |
| SMC Computer AG | Zurich |
| SMC Swiss Management Center AG | |
| Smeetz S.A. | |
| Smile Suisse S.A. | Vaud |
| Smile-Supporting | Aargau |
| Smixin | Bern |
| SMT Swiss Mains GmbH | Aargau |
| Snipd | |
| Snowflake Productions GmbH | Zurich |
| SO REAL Digital Twins AG | |
| Soberano-Sourcing GmbH | Bern |
| Société Générale in Switzerland | |
| Sodatech AG | Schwyz |
| Soft Gestion | Fribourg |
| SOFTplus Entwicklungen GmbH | Zug |
| SoftRain | Bern |
| Software Development Conferences | Vaud |
| Software Engineerg Michel | Basel-Stadt |
| Software Service & Innovation | |
| Software Support Reich | Thurgau |
| Softwareentwicklung von Programmierer Markus Winter | Ticino |
| SoftwareONE | Nidwalden |
| Sogema Group GmbH | Zurich |
| SoHHytec S.A. | |
| Solana Foundation | |
| Solar-ICT | |
| Solcept AG | Zurich |
| Solenix Engineering GmbH | |
| SolNet | Solothurn |
| Solstis S.A. | Vaud |
| SolusVM | |
| Solutions 4 All | Zurich |
| Solvias AG | |