| Rüfenacht AG | Bern |
| Rumox AG | Zurich |
| Runway Incubator | |
| Rythmik S.à r.L. | |
| S-PRO AG | |
| Sachs Associates Switzerland AG | |
| SAEKI Robotics AG | |
| Safe Ecosystem Foundation | |
| SafeSolution GmbH | |
| Sahoma Controlware | |
| SAI ERP | Valais |
| Saiba AG | |
| SalesWings | |
| Salt Mobile S.A. | |
| Salvisberg Software & Consulting | Bern |
| SAMA Partner AG | Schwyz |
| SamanTree Medical S.A. | |
| SampleZone GmbH | |
| Samsung Electronics Switzerland GmbH | Zurich |
| Sandbox | |
| Sandpiper Digital Payments AG | |
| Sansoft GmbH | St. Gallen |
| Santhera Pharmaceuticals Holding AG | |
| Santiment AG | |
| SapAngel S.A. | Geneva |
| Saphetor S.A. | |
| Saphetor S.A. | |
| SAPIENTROQ GmbH | |
| Saporo S.A. | |
| Sat4M2M AG | |
| Satel Service S.A. | Geneva |
| Satomec AG | Zug |
| Satshop Handels GmbH | Aargau |
| Sawatec AG | |
| SayNode Operations AG | |
| SBI Software Beratungs-Institut AG | Basel-Landschaft |
| Scailyte AG | |
| Scala Programming Language | |
| Scan-Tech-Services | Zurich |
| Scandens GmbH | |
| Scantrust S.A. | Vaud |
| Scheuss & Partner AG | Zurich |
| Schibli Support AG | St. Gallen |
| SCHILLER-Reomed AG | |
| Schmid Elektronik AG | Thurgau |
| Schneider Software AG | Zurich |
| Schuler Engineering GmbH | Lucerne |
| Schurter Holding AG | Lucerne |
| Schweizer Digitaltage | |
| Schweizer Hochschule für Logopädie Rorschach | |