| Somagenetix | |
| SonarSource S.A. | |
| Sonceboz S.A. | |
| Sonect AG | |
| Soneris Realtime GmbH | Zurich |
| Sophia Genetics S.A. | |
| Soprotec Formations S.A. | Geneva |
| Sorba EDV AG | St. Gallen |
| Soreco AG | Zurich |
| SOSdonnées.ch | Geneva |
| SoundChip S.A. | Vaud |
| Sourcepole AG | Zurich |
| Soverli AG | |
| Soxes AG | |
| Space for Business | |
| Space Innovation | |
| SPACE Metaverse AG | |
| SpacePharma S.A. | |
| SpaceQuest Ventures | |
| Spacetek Technology AG | |
| Spar+Leihkasse Gürbetal SLG | |
| Spar+Leihkasse Riggisberg AG | |
| Spar- und Leihkasse Bucheggberg A | |
| Spar- und Leihkasse Frutigen AG | |
| Spar- und Leihkasse Wynigen AG | |
| Sparkasse Schwyz AG | |
| SPB TV AG | |
| Spectroplast AG | Zurich |
| Spectrum Dynamics Medical | |
| Spengler Electronic AG | Basel-Landschaft |
| SperiLogic | Solothurn |
| Spescha Visual Design | Grisons |
| Spexis | |
| Spiden AG | |
| SpiderWeb | Aargau |
| Spineart | |
| SpinningBytes AG | |
| SpiroChem AG | |
| Sportradar AG | |
| SpotMe | |
| SprITecs | |
| SQD | |
| Squirro AG | |
| ST Concept | |
| Staff Augmentation | |
| Stalicla | |
| Stallergenes Greer | |
| Stardesign | Bern |
| Starmind | Zurich |
| START Global | |