| Edinburgh Napier University - School of Computing, Engineering & The Built Environment | Edinburgh |
| Edinburgh Perl Mongers | Edinburgh |
| Edinburgh Software Ltd | |
| Edinburgh Web | Edinburgh |
| Edinburgh Web Designs | Edinburgh |
| Edinburgh Websites | Edinburgh |
| edirect | |
| Edited | |
| Edmonds Commerce Ltd | West Yorkshire |
| Edmondson's IT Services | |
| Edmund Optics Ltd | North Yorkshire |
| Edna App | |
| EDOT3 | Tyne and Wear |
| EDS (UK) | Lancashire |
| EDSA Designs Ltd | Devon |
| Edubuntu | Isle of Man |
| Education Ecosystem | |
| Education Software Services Ltd | |
| Education Software Solutions Ltd | |
| Educational Voice | |
| Edukey Education Ltd | Pembrokeshire |
| Edumentors | |
| Edurio | |
| Edutech Zone Ltd | |
| Edward Robertson Digital Design and Development Agency | |
| Edworthy Media and Technology Ltd | |
| EDX Medical Group plc | |
| EE Ltd | |
| Eelpower | |
| Eemits Communications | North Yorkshire |
| eezytrade | Shropshire |
| eFeed | |
| Effect Digital Ltd | |
| Effect Systems Ltd | Berkshire |
| EffecTech | |
| Effective Marketing (GB) Ltd | Leicestershire |
| Effective Multimedia | Suffolk |
| Effective Webs | Devon |
| Efflinch Dot Com | Staffordshire |
| Effortless Digital Services Ltd | |
| Effra | |
| eFiling | Northamptonshire |
| eflow Ltd | |
| eforeknowledge | West Midlands |
| eg technology Ltd | |
| Egenica | Lancashire |
| Egham Tech | |
| EGN Systems Ltd | East Sussex |
| Ego-Design Ltd | Derbyshire |
| Egress Software Technologies Ltd | |