| eCommonSense | Nottinghamshire |
| EcomSolutions | |
| Econic Biosciences | |
| Economic Data Sciences Ltd | |
| eConsult Health Ltd | |
| Econsultancy | |
| EcoOnline | Merseyside |
| eCosCentric Ltd | Cambridgeshire |
| Ecosse Property Ltd | |
| Ecosse Reference Cable | East Ayrshire |
| EcoSync Ltd | |
| eCourier | |
| Ecrebo | Berkshire |
| Ecru Design Ltd | Glasgow |
| ECSC | West Yorkshire |
| ECSWeb | Hampshire |
| Edan Kwan | |
| edan.io Coop | |
| EDAS Computers | Cambridgeshire |
| Eddison Media | Cheshire |
| Eddystone Broadcast Ltd | Warwickshire |
| Eddystone Media | Devon |
| Eden Agency Ltd | North Yorkshire |
| Eden Bio Ltd | |
| Eden Grafix | |
| eDesk Solutions | |
| Edeva Solutions Ltd | |
| Edge by Ascential | |
| EDGE Creative | |
| Edge Hill University | |
| Edge Interactive Ltd | |
| Edge IT Systems Ltd | |
| Edge of the Web Ltd | |
| Edge VC | |
| Edge45 Ltd | North Yorkshire |
| Edgewords Ltd | Shropshire |
| Edgify | |
| Edgywebsites Ltd | |
| Edible Marketing Ltd | Merseyside |
| Edico Media Ltd | Bristol |
| EdICT Training Ltd | Glasgow |
| Edifice Managed Access Ltd | |
| Edinburgh BioQuarter | |
| Edinburgh Futures Institute | |
| Edinburgh Hacklab | |
| Edinburgh Innovation Labs Ltd | |
| Edinburgh Innovations Ltd | Edinburgh |
| Edinburgh Mathematical Society | Edinburgh |
| Edinburgh Molecular Imaging | |
| Edinburgh Napier University | Edinburgh |