| Smart Ink | |
| SMART Photonics | |
| Smart Profile | |
| SMART Research B.V. | Gelderland |
| Smart Robotics | |
| Smart-Ship B.V. | |
| Smart.pr | |
| Smartchecked | |
| Smartdc | |
| SmartDocuments | Overijssel |
| SmartHOTEL | South Holland |
| Smartlockr | |
| Smartmile | |
| Smartocto | Gelderland |
| smartQare | |
| SmartRanking | Groningen |
| SmartSV | |
| Smartwares Group | North Brabant |
| smeGo Netherlands B.V. | |
| Smidt Kennisprovider | Drenthe |
| SMT | South Holland |
| Snakeware | Friesland |
| SnappCar | |
| Snapput B.V. | |
| SnelStart | North Holland |
| Snirp | |
| Snoeren Automation | North Holland |
| Social Blue | North Holland |
| SocialReblz | South Holland |
| Societe Generale, Amsterdam Branch | |
| Socofi Weboplossingen | North Brabant |
| Soeteman Software | |
| Softbrick B.V. | Gelderland |
| Softec Technologies | |
| Softmedia | |
| Softpak B.V. | South Holland |
| SoftTech | South Holland |
| Software inzicht | Utrecht |
| Softwarebevers | North Holland |
| Softwaregids | North Holland |
| Softwarepakketten.nl | North Holland |
| Softwareplan | Flevoland |
| Softwell | North Holland |
| Sogeti Nederland B.V. | Utrecht |
| Sogyo B.V. | Utrecht |
| Soko B.V. | North Holland |
| Solar Monkey | |
| Solar-systemen.nl | |
| SolarDuck B.V. | |
| Solcon Internetdiensten B.V. | Flevoland |