| SuperPass | Ontario |
| Superscope Media, Inc. | Ontario |
| SuperVisas | |
| SuperWebHost | British Columbia |
| Supply Chain Alliance Ltd | |
| Supply Chain Canada | |
| Support 514 | |
| Support E-Media | Quebec |
| Support-systeme-information.com | Quebec |
| Supportbench | |
| Supportech Informatique, Inc. | Quebec |
| SUPPORTECH, Inc. | Ontario |
| SupportLINK Systems, Inc. | British Columbia |
| SupraITS | Ontario |
| Supramega | |
| Supreme Computing Services Co. | Ontario |
| Supreme Creations | |
| Supremesoft Corporation | Ontario |
| Sure Systems | |
| SureFire Capital | |
| Surety Partners, Inc. | |
| Surf22 | Quebec |
| SurfEasy | Ontario |
| SurfWare Labs | Quebec |
| Surge | |
| Surgeboom | Ontario |
| SurInternet.ca | Quebec |
| Surrey Geeks | |
| Surtek Industries, Inc. | British Columbia |
| Sussex Telecom, Inc. | Ontario |
| Sustainable Development Technology Canada | Ontario |
| SustaiNet Software International, Inc. | |
| Sustainet Software Solutions, Inc. | British Columbia |
| Sustane Technologies, Inc. | |
| Sustema | Quebec |
| SUTCAST Software Technology, Inc. | British Columbia |
| SV ChemBioTech | |
| Svet-Soft | British Columbia |
| SVI eSolutions, Inc. | Quebec |
| Svice Online Marketing | |
| SVX | |
| Swagman Software, Inc. | Ontario |
| Swan Technologies | |
| Swank Collective | |
| Swansea Computer Specialists Corporation | Ontario |
| Swap Robotics | |
| Swarmio Media | Nova Scotia |
| SWD | Manitoba |
| Sweeney International Marine Corporation | |
| SweetScape Software, Inc. | Prince Edward Island |