| SyntecX Canada | |
| Syntell, Inc. | Quebec |
| SYNTHÈSE – Pôle Image Québec | |
| Synthetic Realms | Alberta |
| Synthiam | |
| Synucure Therapeutics | |
| Syonex | |
| SYR Systems, Inc. | |
| Syreon Corporation | |
| Sys Concept, Inc. | Alberta |
| SyS Creations | Ontario |
| Sys-X Corporation | Ontario |
| SysAIO | |
| SysAIO, Inc. | Ontario |
| Sysbu | |
| Syscal.com | Alberta |
| Syscan RS | Quebec |
| Syscon Justice Systems | British Columbia |
| SysEne Consulting, Inc. | |
| SysgGen | Alberta |
| Sysguy Consulting | Alberta |
| Sysimple | |
| Syslogix | |
| Sysmarc, Inc. | Ontario |
| Sysmic Informatique, Inc. | Quebec |
| Sysmik | Quebec |
| SysNergie, Inc. | |
| SYSNOV Company, Inc. | |
| Sysoft.ca, Inc. | Ontario |
| Sysomos | Ontario |
| Syspark | Quebec |
| Syspro | British Columbia |
| Systelligence | |
| System and Network Solutions | Ontario |
| System Architects, Inc. | Ontario |
| System Dynamics Corporation | Ontario |
| System Information for Windows | Ontario |
| System Solutions | Nova Scotia |
| System-3 | |
| System-On-Chip (SOC) Technologies | Ontario |
| Systema Solutions | |
| Systematix | Quebec |
| Systematix, Inc. | Ontario |
| SystemCore Computer, Inc. | |
| Système Comptable Oasis | Quebec |
| Systèmes Acquiro, Inc. | Quebec |
| Systèmes Aéronautiques d’Avant-Garde pour l’Environnement | |
| Systèmes humains-Machines, Inc. | Quebec |
| Systèmes informatiques Innologix | Quebec |
| Systèmes Mobilis | Quebec |