| SweetSop Design | Ontario |
| Swell YYC | |
| Swept Technologies, Inc. | Nova Scotia |
| Swerve Design Group, Inc. | Ontario |
| Swhistle Soft | Ontario |
| Swift Ads, Inc. | |
| Swift Current Chamber of Commerce | |
| Swift Design | Ontario |
| Swift Media | Alberta |
| Swift Medical, Inc. | |
| SwiftCharts | Ontario |
| SwiftSure Innovations | Newfoundland and Labrador |
| SwingTrackr | |
| SwipeReach | Nunavut |
| SwissTech Consulting | British Columbia |
| Switch Creative | Ontario |
| Switch United | British Columbia |
| Switchboard | British Columbia |
| Switchclick | Ontario |
| SwitchWorks Technologies, Inc. | Ontario |
| Swob, Inc. | |
| Swoo | Quebec |
| Sword & Source | |
| SWTCH Energy, Inc. | |
| Swyft Courier | |
| Syacc Systems, Inc. | Ontario |
| Syantra, Inc. | |
| Syban Systems Ltd | Alberta |
| SyberWurx Dot Com, Inc. | Ontario |
| Syclone | Quebec |
| Sydnic Computer Systems, Inc. | Ontario |
| Syfacte | |
| Sygertech | |
| Syl Disjonk | Quebec |
| Syllogix, Inc. | Quebec |
| Sylogique Médias | Quebec |
| Sylogist | Alberta |
| SyLogix Consulting, Inc. | Ontario |
| Symatron Corporation | Ontario |
| Symbicore | |
| Symbiosys | |
| SymbioTIC | |
| Symbiotic Software, Inc. | British Columbia |
| Symcod | Quebec |
| Symend | |
| Symetric Productions, Inc. | Ontario |
| Symetris Digital Partner | Quebec |
| Symplify Technologies | |
| Symtech Innovations Ltd | |
| Symvision | Quebec |