| Sizwe Africa IT Group | Gauteng |
| SK Telecom (Pty) Ltd | Gauteng |
| Skylight Digital | |
| Skyrove | Western Cape |
| Skytouch Hosting | |
| Skytouch Media | Western Cape |
| Skywalk Innovations | |
| SLK Projects | |
| Slyce Online | Gauteng |
| small BITS Software CC | Gauteng |
| SmallBizCRM | Western Cape |
| Smart Digital Media | Western Cape |
| Smart Options | Western Cape |
| Smart Retail | Gauteng |
| Smart SEO | KwaZulu-Natal |
| Smart-IT | Western Cape |
| SmartBlade | |
| SmartMob (Pty) Ltd | |
| SmartVoice | Gauteng |
| Smartweb Group (Pty) Ltd | Western Cape |
| SmartXchange | KwaZulu-Natal |
| Smith Capital Equipment (Pty) Ltd | |
| Smollan | |
| Smudge | Gauteng |
| SnapBill (Pty) Ltd | Western Cape |
| Snapt | Western Cape |
| SNWS Digital | |
| So Interactive | Gauteng |
| Soft Edge Solutions | Gauteng |
| Softh African Software House | |
| Softillion | |
| Softnet | Free State |
| Softoit | Gauteng |
| SoftPageCMS | Western Cape |
| Softserve | |
| SoftSmart Tech (Pty) Ltd | |
| Software Africa | Gauteng |
| Software Colors (Pty) Ltd | Western Cape |
| Software Control Services (Pty) Ltd | Gauteng |
| Software Farm | Gauteng |
| Software Testing Solutions (Pty) Ltd | Gauteng |
| Sol Plaatje University | Northern Cape |
| SolarWorks | |
| Solid Systems | Western Cape |
| Solumed | Gauteng |
| Solution Technologies | Gauteng |
| Solutioncoms | Gauteng |
| Somco Cape | Western Cape |
| SOS Web Services | KwaZulu-Natal |
| Sound Idea Productions | Gauteng |