| RLabs | Western Cape |
| Robertson Valley Technologies | Western Cape |
| Robot Dwarf | |
| Rocketsoft | |
| Rocksolid Systems | Western Cape |
| Rogerwilco | Western Cape |
| RogueWeb (Pty) Ltd | |
| Rokkit Digital Agency | |
| RoseStreet Systems | Gauteng |
| Rox Computers | Gauteng |
| RSAWEB | Western Cape |
| RsR IT Solutions | Gauteng |
| Ruby Digital | |
| Ruby Sky | Gauteng |
| Ruby Web Solutions | |
| RuggedMobile | Gauteng |
| Running Computers | Gauteng |
| Runninghill Software Development | |
| Rural Brands | |
| Rylurx IT | Western Cape |
| S2 Web Solutions | Western Cape |
| SA Domain Internet Services | Gauteng |
| SA Domains | Gauteng |
| SA Game Dev | Gauteng |
| SA Innovation Summit | Western Cape |
| SA SME Fund | |
| SA Web Designer | Western Cape |
| SA Webhosts | |
| SA Webs | KwaZulu-Natal |
| Sa Wireless | Gauteng |
| SA-Gateway | Gauteng |
| SA-Nethost.com | Western Cape |
| SAAMBR | |
| Sabvest Capital Ltd | |
| Sage Intelligence | KwaZulu-Natal |
| Sage South Africa (Pty) Ltd | Gauteng |
| Saglotech IT Solutions (Pty) Ltd | |
| saHOSTplus.com | KwaZulu-Natal |
| SAIGEN | |
| Salestronics CC | Western Cape |
| Sand Design Studio | Gauteng |
| Saratoga | Western Cape |
| Saros Consulting | Western Cape |
| SASA Finance (Pty) Ltd | Western Cape |
| Sasfin | |
| Satellite Communication | Gauteng |
| Satellite Connection | Limpopo |
| Savant | Western Cape |
| Savit52 | |
| Savuti Communications | Gauteng |