| Raramuri Design | Western Cape |
| Raw IT | Gauteng |
| Rayoni Web Solutions (Pty) Ltd | |
| RDB Consulting | Gauteng |
| Real Pay Pty Ltd | |
| Realm Digital | |
| Realtime | Western Cape |
| Realyst Contract Management Ltd | Gauteng |
| Recor | Gauteng |
| Rectron (Pty) Ltd | |
| Red Dor | |
| Red Dot | KwaZulu-Natal |
| Red Herring Digital | Gauteng |
| Red Internet | Gauteng |
| Red Orchid Projects | Western Cape |
| Red Panda Software | Western Cape |
| RedButton | Western Cape |
| RedHot Design | |
| RedNinja Design Studio | Gauteng |
| redPanda Software | |
| Redshift Cyber Security | Western Cape |
| Rees Dynamic | Western Cape |
| Reflex Solutions | Gauteng |
| Refresh Creative Media | Western Cape |
| Regenesys (Pty) Ltd | |
| Regenesys Business School (Pty) Ltd | |
| REGENT Business School | |
| Remote Outpost (Pty) Ltd | Gauteng |
| Rentware | Western Cape |
| Republic of South Africa - Department of Science and Technology | Gauteng |
| researchICTafrica.net | Western Cape |
| Restrive | Gauteng |
| Retail Plus Consultancy | Gauteng |
| Rethink Education | Western Cape |
| Retro Rabbit | Gauteng |
| RetroMod Technologies | KwaZulu-Natal |
| Reunert | Gauteng |
| Reutech Communications | KwaZulu-Natal |
| Rhodes University | |
| Rhodes University - Computer Science | Eastern Cape |
| Rhodes University - Department of Information Systems | Eastern Cape |
| Rhodes University - Department of Mathematics | Eastern Cape |
| Richfield Graduate Institute of Technology (Pty) Ltd | |
| Riebens Computers | Western Cape |
| Riecktron Electronics | Gauteng |
| Right Click Media | |
| Ripple Digital | |
| Riva Technology | Gauteng |
| Riversands I-Hub | Gauteng |
| RJ45 Networking Solutions | Western Cape |