| Stratasys Ltd | Central District |
| Stratigo Creative Consultants | Central District |
| Stratoscale | Tel Aviv District |
| Strigo | Tel Aviv District |
| StuccoMedia | Tel Aviv District |
| StuffThatWorks | |
| SuperCom | Tel Aviv District |
| SuperSmart | Tel Aviv District |
| Superwise | Tel Aviv District |
| SURE Universal Ltd | Tel Aviv District |
| Svivot | Central District |
| SWAPP | Tel Aviv District |
| Sweb | Tel Aviv District |
| Sweet Security | Tel Aviv District |
| SweetHome | Tel Aviv District |
| Sygnia, Inc. | Tel Aviv District |
| Symbol | Tel Aviv District |
| Synel | Tel Aviv District |
| Synergy Cables | |
| Synergy Cables Ltd | Southern District |
| Synerion Systems Ltd | |
| Syqe Medical | Tel Aviv District |
| SysBind Ltd | Central District |
| Sysmop technologies Ltd | Northern District |
| Sysnet Group | Tel Aviv District |
| Systematics | Tel Aviv District |
| Syte | Tel Aviv District |
| Tabnine | Tel Aviv District |
| Tabor Electronics Ltd | Haifa District |
| Taburit | |
| Tactile-Mobility | Haifa District |
| Tadam | Tel Aviv District |
| Taditel Ltd | Central District |
| TaKaDu Ltd | Central District |
| Takwin | Haifa District |
| Tal Daniel | Tel Aviv District |
| Taldor | Tel Aviv District |
| TalknSave | Jerusalem District |
| Tamal | Tel Aviv District |
| Tamares Telecom | Tel Aviv District |
| Tamir Fishman | |
| TandemG | Central District |
| TankU | Haifa District |
| Tao Software Development Company | Tel Aviv District |
| Target Venture | |
| Targetgene Biotechnologies | Central District |
| Taro Pharmaceutical Industries Ltd | Haifa District |
| Tarom Applied Technologies Ltd | |
| Tarsier Pharma Ltd | Haifa District |
| Tarya | Central District |