| Name | Region |
|---|---|
| Shield | Tel Aviv District |
| Shilat Optronics Ltd | |
| Shina Systems Ltd | Haifa District |
| Shine | |
| Shkedim Studio | Tel Aviv District |
| SHL Telemedecine | Tel Aviv District |
| Shm.co.il | Tel Aviv District |
| Shooker | |
| ShopCenter | Tel Aviv District |
| Shopic | Tel Aviv District |
| ShopSystem | Tel Aviv District |
| Shva | |
| Siftech | Jerusalem District |
| Sig Software | Tel Aviv District |
| Sight Diagnostics | Tel Aviv District |
| Sight Diagnostics Ltd | Tel Aviv District |
| Sightfull | Tel Aviv District |
| Signature-IT | |
| Signup | Tel Aviv District |
| Silentium Ltd | Central District |
| Silicom Ltd | Central District |
| Silverbyte Ltd | Haifa District |
| Silverfort | Tel Aviv District |
| Simetria | Central District |
| Simigon | Tel Aviv District |
| SimilarTech Ltd | Tel Aviv District |
| Simple Idea | |
| Simplex by Nuvei | Tel Aviv District |
| Simplivia Healthcare Ltd | |
| Simply AD | |
| Simply Ltd | |
| Sinapis | |
| Sinapis Technologies Ltd | Central District |
| Singer-Instruments and Control Ltd | Haifa District |
| Singular | Tel Aviv District |
| Singulariteam Ltd | Tel Aviv District |
| Sion Medical Ltd | |
| SIT | Tel Aviv District |
| Sital Technologies | Central District |
| Site123 | Southern District |
| Site4u | Tel Aviv District |
| Siteflex | Haifa District |
| Sivan Design D.S. Ltd | Central District |
| Sixdof Space Ltd | Jerusalem District |
| Sixgill | Central District |
| SkillVenue | |
| Skip Therapeutics | |
| Skyfund | Tel Aviv District |
| Skyline Robotics | |
| SleepRate | Tel Aviv District |