| DIC | Tel Aviv District |
| Digidam Design | Jerusalem District |
| DigiKey | |
| Digital Confidence Ltd | Tel Aviv District |
| Digital Journey | |
| Digital Secrets | |
| Digital Vibe | |
| DigitalIST | Tel Aviv District |
| Digitaliz Web Solutions | |
| Digitize | Tel Aviv District |
| Dino | Tel Aviv District |
| Dio Tree | |
| Diolan | Central District |
| Dip-Tech Digital Printing Technologies Ltd | Central District |
| DiscMan | Tel Aviv District |
| Discount Capital | Tel Aviv District |
| Discount Tech | |
| DiscoverCloud | Tel Aviv District |
| DiscoverSDK | Haifa District |
| Discure Technologies | |
| Disruptive | Tel Aviv District |
| Disruptive AI | Tel Aviv District |
| DISSEN Software, Bar & Grill - Israel Ltd | Jerusalem District |
| Divi8 | Tel Aviv District |
| Dixel Electronics Ltd | Central District |
| Do4u | Tel Aviv District |
| DocAuthority | Central District |
| Docktech | Tel Aviv District |
| Dofinity Ltd | |
| Dokka A.I. Ltd | Tel Aviv District |
| Domain The Net | Tel Aviv District |
| Dooble | Northern District |
| Doral Tech Ventures | |
| DoroTree | Jerusalem District |
| Dotcom Israel | Tel Aviv District |
| DoubleTeam | Tel Aviv District |
| DrAlex Software | Central District |
| Dream-Security Ltd | |
| Dreamium Ltd | Tel Aviv District |
| DreamsDesigners | Tel Aviv District |
| Dreamview | Tel Aviv District |
| Driivz Ltd | |
| Drive TLV | Tel Aviv District |
| DriveNets | Central District |
| Driveu Tech Ltd | Central District |
| Drix.co.il | Tel Aviv District |
| DRP.co.il | Tel Aviv District |
| Drushim IL | |
| DSIT Solutions Ltd | Central District |
| DSNR Media Group | Central District |