| ColorChip | Northern District |
| Colugo | Central District |
| Com-C-Tech Ltd | Tel Aviv District |
| Com-Future | Jerusalem District |
| Com-Sense (IoT) Ltd | Tel Aviv District |
| COM.UNITY | Tel Aviv District |
| Combix | Jerusalem District |
| Comda | Tel Aviv District |
| Commodore Information Systems | Tel Aviv District |
| CommonGround-AI | Tel Aviv District |
| Commtact | |
| Commugen | Tel Aviv District |
| Commun.it | Tel Aviv District |
| Como | Central District |
| COMP4U | Tel Aviv District |
| Companics Communication & Electronics Ltd | Central District |
| Complete Business Solutions | Tel Aviv District |
| Comply Ltd | Central District |
| Compucraft Ltd | Tel Aviv District |
| Compugen | Tel Aviv District |
| CompuHedge | Jerusalem District |
| CompuLab Ltd | Northern District |
| Compumedia | Tel Aviv District |
| CompuMedic | Tel Aviv District |
| CompuSale | Jerusalem District |
| Computer C-Data Ltd | Central District |
| Computrade | Central District |
| Comrax | Tel Aviv District |
| Comsec Consulting | Central District |
| Comsign | Tel Aviv District |
| Conceptic Interactive Menus | Central District |
| Configu | Tel Aviv District |
| ConKor Systems Ltd | Northern District |
| Connecteam.com | Tel Aviv District |
| Consist Software Solutions | Tel Aviv District |
| Conspect Ltd | Central District |
| ConTech | Tel Aviv District |
| Contel Technologies | Central District |
| Control Applications Ltd | Tel Aviv District |
| Copia Agro & Food | Tel Aviv District |
| CopterPix | Southern District |
| Corephotonics Ltd | Tel Aviv District |
| CoreTigo | Central District |
| CoroNet | Tel Aviv District |
| Corsight AI | Tel Aviv District |
| Cortica | Tel Aviv District |
| Council for Higher Education | |
| Craft.io | Tel Aviv District |
| Crossroad Venture Capital Fund | Tel Aviv District |
| Crowdsense | Tel Aviv District |