| Biomedia Ltd | Tel Aviv District |
| Biomica | Central District |
| BiomX | Central District |
| Biond Biologics | Northern District |
| Biop Medical | Tel Aviv District |
| BioProtect Ltd | Central District |
| BioRap Technologies Ltd | |
| BioT Medical | Central District |
| Bioxtreme | Central District |
| BIRAD - Research and Development Company Ltd | |
| BIS Solutions | Tel Aviv District |
| Bit-Gem | |
| Bizibug | Tel Aviv District |
| Biztec | Tel Aviv District |
| BlaBla4U | Tel Aviv District |
| Blau Pharmaceutical Services | |
| BlazePod Israel | Central District |
| Bllink | Tel Aviv District |
| Blockaid Ltd | |
| BloomX Ltd | Central District |
| Blox Staking | Tel Aviv District |
| Blue White Robotics | Tel Aviv District |
| Blum Web Design | Tel Aviv District |
| bmby Software Systems Ltd | Northern District |
| bondIT | Tel Aviv District |
| Bonus BioGroup Ltd | |
| Bookaway | Tel Aviv District |
| Booya Digital | Tel Aviv District |
| BOS | Central District |
| BOS-Odem Ltd | Central District |
| Botika | Tel Aviv District |
| BQR Reliability Engineering | Central District |
| Braavos | Tel Aviv District |
| BrainsGate | |
| Brainsway | Jerusalem District |
| Brave | Tel Aviv District |
| Breakthrough Ltd | Central District |
| Breakthrough Ltd | |
| BRH Medical | Jerusalem District |
| Briefery Ltd | Central District |
| Bright Data Ltd | Central District |
| Bright Innovations Co. | Haifa District |
| Brightmerge Ltd | Central District |
| Bringg | Tel Aviv District |
| Britannica Knowledge Systems | Tel Aviv District |
| BRM Group | Tel Aviv District |
| BroadTec Software Solutions Ltd | Jerusalem District |
| Brossh | Northern District |
| BSmart Web Application | Tel Aviv District |
| BUFFERZONE Security Ltd | Tel Aviv District |