| SpeedBuilder Systems | South Carolina |
| Speedchain, Inc. | |
| SpeedConnect | Michigan |
| SpeedeCoder | Arizona |
| Speedeon Data | Ohio |
| SpeedGuide, Inc. | Florida |
| Speedify | |
| Speedlancer, Inc. | |
| Speedment, Inc. | California |
| Speedsquare | |
| Speedtest by Ookla | |
| SpeedTrack, Inc. | California |
| Speedwell Holdings, LLC | Nevada |
| SpeedyBrand | California |
| SpeedyPaper | |
| SpeedySoft USA, Inc. | Florida |
| SpeedyTech | California |
| Speid & Associates, Inc. | |
| Speid & Associates, Inc. | |
| Spekit | |
| Spektion | Texas |
| Spell | New York |
| Spellex Corporation | Florida |
| Spellman High Voltage Electronics Corporation | New York |
| Spellmann & Associates | Texas |
| Spelman College | Georgia |
| Spencer Haley | California |
| Spencer Learning | California |
| Spencer Stuart | |
| Spencer Technologies | Massachusetts |
| Spencer Web Design | Missouri |
| Spendbase | |
| Spendflo, Inc. | California |
| Spendgo, Inc. | |
| SpendHQ | |
| SpendMend | |
| Spendwise, Inc. | |
| Spenz Media | |
| Sperantus | |
| Sperco | Illinois |
| Spericorn Technology, Inc. | |
| Speridian Technologies, LLC | New Mexico |
| Sperling Interactive | |
| Spero Therapeutics | |
| Spero Ventures | |
| Speros, Inc. | Georgia |
| Sperry Repair | Nebraska |
| Sperry Software, Inc. | Florida |
| Sperse, LLC | |
| SPES Pharmaceutical, Inc. | |