| Sparrow & Finch, Inc. | |
| Sparrow Corporation | Florida |
| Sparrow Pharmaceuticals, Inc. | |
| Sparta Biomedical | North Carolina |
| Spartan College of Aeronautics and Technology | Oklahoma |
| Spartan Digital | Texas |
| Spartan Electronics, Inc. | Massachusetts |
| Spartan Micro, Inc. | California |
| Spartanburg Methodist College | South Carolina |
| SparTech Software | Texas |
| SparX Biopharmaceutical | |
| Sparx Technology, LLC | |
| Sparxell, Inc. | |
| Spatial Business Systems, Inc. | Colorado |
| Spatial Data Consultants, Inc. | North Carolina |
| Spatial Data Logic | New Jersey |
| Spatial Digital Social, Inc. | California |
| Spatial Genomics, Inc. | California |
| Spatial Laser, Inc. | Texas |
| Spatial Systems, Inc. | New York |
| Spatial.ai | Ohio |
| Spatialitics, LLC | |
| SpatialPoint, LLC | Illinois |
| SpatialVerse | |
| SpatialX, Inc. | |
| Spaulding Clinical Research, LLC | Wisconsin |
| Spawn Solutions | |
| SPD Hosting | |
| Speak Creative, LLC | Tennessee |
| Speak Social | |
| Speakable | |
| Speakap, Inc. | New York |
| Speakeasy Labs, Inc. | |
| Speakeasy, Inc. | |
| Speaker Deck, LLC | |
| SpeakerFlow | Wyoming |
| Speaking Socially | |
| Speak_ | Colorado |
| Spear Bio | Massachusetts |
| Spear Education, LLC | |
| Spear Marketing Group, Inc. | California |
| Spear Technologies | |
| Spearhead Technology | Texas |
| Spears Computer World | Arkansas |
| Speartek | Georgia |
| SpecCheck Technologies, Inc. | |
| Special Aerospace Services | |
| Special Agent, Inc. | Massachusetts |
| Special Cable Deals | Colorado |
| Special Computing | Arizona |