| SpexHost, LLC | New York |
| SPE·ED+ | Texas |
| spf13 | |
| SpftwareHubs.com | Wyoming |
| SPG Web + Marketing, LLC | |
| SphenoCath | Utah |
| Sphera | Illinois |
| Sphere Entertainment Group, LLC | |
| Sphere Laboratories, Inc. | |
| Sphere of Influence, Inc. | Virginia |
| Sphere Software, LLC | Illinois |
| SPHERE Technology Solutions | New Jersey |
| Sphere, Inc. | California |
| SphereCommerce, LLC | New York |
| SphereGlobal | |
| SphereMail, Inc. | California |
| SphereOne | Texas |
| SphereWMS | Colorado |
| Spherexx, LLC | Oklahoma |
| Spheric | |
| Spherical | |
| Sphero, Inc. | Texas |
| Spherotech, Inc. | Illinois |
| Sphinx | Washington |
| Sphinx Medical Technologies, Inc. | California |
| SPI Connects | Ohio |
| SPI Software | Florida |
| SPI/Semicon | California |
| Spiber, Inc. | |
| Spica Technology Corporation | Washington |
| Spice AI, Inc. | Washington |
| SpiceCSM | Florida |
| SpiceFactory | |
| Spiceworks, Inc. | Texas |
| SpiceX | |
| Spicy Tribe | |
| Spider Choice, Inc. | |
| Spider Strategies, Inc. | Virginia |
| Spider Tech Support, LLC | Florida |
| Spider Woman Web Design | Virginia |
| Spiderboost Communications | |
| Spiderhost | Florida |
| Spiderlink Web Services, Inc. | California |
| SpiderMount | Colorado |
| SpiderOak | District of Columbia |
| Spiderweb Software, Inc. | Washington |
| Spidr Design, Inc. | |
| SPIDR Tech | California |
| Spidy Tech Solutions | |
| SPIE | Washington |