| eTraverse | |
| eTX Data Services | KwaZulu-Natal |
| Euphoria Software | Gauteng |
| Euphoria Telecom (Pty) Ltd | Western Cape |
| EuroByte Online | Gauteng |
| Eurotel | Western Cape |
| Evaluate Assessment Solutions (Pty) Ltd | Gauteng |
| EvaluNet | Western Cape |
| Evan Ross | |
| EvenFlow | Western Cape |
| Ever Dgitial Marketing | Gauteng |
| Everett Computer Consultantd | Gauteng |
| Everlectric | |
| Everlytic | Gauteng |
| Evo-V (Pty) Ltd | |
| Evolvea Systems | |
| Evolving Management Solutions | Gauteng |
| Exalon Dynamic Systems | KwaZulu-Natal |
| Exceed IT | |
| Excel-Skills.com | Western Cape |
| Exclaim Innovations | Gauteng |
| Exclusive Web Design | KwaZulu-Natal |
| Execmail IT Solutions | Gauteng |
| ExoSystems | |
| Exousia Consultants | |
| Face Technologies | Gauteng |
| FailSafe Systems | KwaZulu-Natal |
| False Bay TVET College | |
| FAQ (Pty) Ltd | Western Cape |
| Faranani | Gauteng |
| Fast Forward Marketing | |
| FastSite | Gauteng |
| Fathom Data | |
| FDCS | Gauteng |
| FDesign | Western Cape |
| FGX Studios | Gauteng |
| Fibretronics Sales (Pty) Ltd | Eastern Cape |
| Financial Sector Conduct Authority | |
| FinChatBot | Gauteng |
| Fincheck.co.za | |
| FinComp Technologies | Gauteng |
| Fingerprints Software (Pty) Ltd | |
| Finstone Information Technologies (Pty) Ltd | Gauteng |
| Fir3storm Technology | |
| Firewater Interactive | Gauteng |
| Fireworkx | Western Cape |
| First Coast Technologies | Western Cape |
| First Distribution | Western Cape |
| First Technology | Free State |
| FirstNet | KwaZulu-Natal |