| Dynamic IT Solutions | Gauteng |
| Dynamic Visual Technologies (Pty) Ltd | Western Cape |
| Dynamics Africa Services (Pty) Ltd | |
| Dynamite | Gauteng |
| E Solutions Automation (Pty) Ltd | Western Cape |
| E Squared | Gauteng |
| E-Jobin | |
| e-Merge | Gauteng |
| E2E Consulting | KwaZulu-Natal |
| EAGLE Technology | Western Cape |
| Eagle-Networking CC | Gauteng |
| EasiWAN | Gauteng |
| Eastern Cape Information Technology Initiative | Eastern Cape |
| Easy Systems Technologies CC | Gauteng |
| Easy2Access | KwaZulu-Natal |
| Easyweb Internet | Gauteng |
| EasyWebz | KwaZulu-Natal |
| Ebiexperts | Gauteng |
| ECAT Online | Gauteng |
| eCenTrix Software | North West |
| Ecom-Solutions.biz | |
| Ecomm Technologies (Pty) Ltd | KwaZulu-Natal |
| Ecommerce Development | |
| eComplete | Western Cape |
| Econet Group | Gauteng |
| Econsultant | Gauteng |
| Eda Technologies | Gauteng |
| Edenvale Computers | Gauteng |
| EDGE Evolve (Pty) Ltd | Gauteng |
| eDisc | Eastern Cape |
| EDM Shop | Gauteng |
| Edot Digital | |
| Edot Web Technologies | Gauteng |
| Ehlanzeni TVET College | |
| Ehost | Western Cape |
| Ekurhuleni East TVET College | |
| Ekurhuleni West Technical, Vocational, Education and Training College | |
| Elancergroups (Pty) Ltd | Gauteng |
| ELDO | |
| Electracorp SA (Pty) Ltd | |
| Electric Sheep Agency | Western Cape |
| Electro Designs | Gauteng |
| Electro Tech Solutions (Pty) Ltd | Gauteng |
| Electronic Ideas | KwaZulu-Natal |
| Electronic Service Centre CC | Gauteng |
| Electronics Incorporated | KwaZulu-Natal |
| Electronics123 | Gauteng |
| Electrum Payments | Western Cape |
| Elegant Works Consulting (Pty) Ltd | Gauteng |
| Elemental | |