| Elemental Studios CC | Western Cape |
| Elevate Internet Marketing | Gauteng |
| Elevate WebDev | |
| Elevation Design | Western Cape |
| Elite Ideas | Free State |
| Elite Mobile | KwaZulu-Natal |
| Elitehost | Gauteng |
| EliteWeb | Western Cape |
| Ellipsys Group | Gauteng |
| ElmMac (Pty) Ltd | KwaZulu-Natal |
| Elnatan Technologies | Gauteng |
| Elula Online | |
| eMD | Gauteng |
| emediaIT | Eastern Cape |
| Emerge Customer Flow Management (Pty) Ltd | Gauteng |
| Empire State Software & Development | |
| Empire Web | |
| Encoresolutions | Gauteng |
| Energia Corporate Solutions (Pty) Ltd | Gauteng |
| Enerweb (Pty) Ltd | Gauteng |
| eNetworks | Western Cape |
| Enfin Energy Finance | |
| Engage Brandcraft | |
| Enigma Designs | Gauteng |
| Entegral Technologies (Pty) Ltd | Gauteng |
| Entelect | |
| Enterprise Outsourcing | Gauteng |
| EnterpriseWorx IT (Pty) Ltd | |
| Envisionit Deep AI (Pty) Ltd | Gauteng |
| Enyuka.com | Gauteng |
| EOH | Gauteng |
| Eons Digital | |
| Epicdev | |
| eProfile | Gauteng |
| Equadoor Web Design & Marketing Services | Limpopo |
| Equation Business Solutions | Western Cape |
| ERC Design | |
| ERS Biometrics | Gauteng |
| Esayidi TVET College | |
| eSG Networks | Gauteng |
| Espero Computer Systems | Gauteng |
| Esquire Technologies | Gauteng |
| ESRI South Africa | Western Cape |
| Essential IT Solutions | Western Cape |
| Estar web design | Western Cape |
| eStart Computer Services CC | Gauteng |
| Estuary Solutions | Western Cape |
| eta College | |
| Etion Create | Gauteng |
| Etraffic | Gauteng |