| Digital Interactive | |
| Digital Marketing Pretoria | Gauteng |
| Digital Planet | Gauteng |
| Digital Platforms | |
| Digital Puppy | Gauteng |
| Digital Science | Gauteng |
| Digital Solution Foundry | |
| Digital Solutions Group | Gauteng |
| Digital Watermelon Design | Gauteng |
| DigitalConnexion | |
| DigitalDomainz.com | Western Cape |
| Digitaliseme | |
| DigitalView | Gauteng |
| DigitalworX | KwaZulu-Natal |
| DigitLab | KwaZulu-Natal |
| Dimsoline | KwaZulu-Natal |
| Direct Distribution Services | Western Cape |
| Disaster Recovery South Africa (Pty) Ltd | Gauteng |
| DiskDrive | |
| DiskDrive | |
| DK Designs | Western Cape |
| DNA Online | Eastern Cape |
| DNS Business | Gauteng |
| DNS Enterprises | Gauteng |
| Dolphin South Africa | Gauteng |
| Domain Solutions SA | Gauteng |
| Domains.co.cz | Gauteng |
| Dominion IT | |
| Donald Jackson | Western Cape |
| Donkerhoek Data | Western Cape |
| DorTeg Networks | Gauteng |
| Dot Cube | Western Cape |
| Dotslash | Gauteng |
| Dotunleashed | Gauteng |
| Dovecor Digital | Gauteng |
| DPA-Training | Gauteng |
| DracoTec | Gauteng |
| Dragonfly Aerospace | Western Cape |
| Dragonfly Marketing | Gauteng |
| Dreamstate Interactive | Gauteng |
| Dren Solutions | |
| Druff Interactive | Gauteng |
| Dsignr Digital | Gauteng |
| Dumel Systems | Western Cape |
| Durban IT Solutions | KwaZulu-Natal |
| Durban University of Technology | |
| Durban University of Technology - Information Technology | KwaZulu-Natal |
| Dutch Ink | |
| Dynacomm Networks | Western Cape |
| Dynamic Communications | Western Cape |