| Diogenius | Walloon Brabant |
| Diomedia | West Flanders |
| Dionamic | Antwerp |
| DISA | Brussels-Capital |
| Discai | |
| Diskldee | Brussels-Capital |
| DMNET-APFF A.S.B.L. | Brussels-Capital |
| DMS Accelerator | |
| DNS Belgium | Flemish Brabant |
| Docbyte | |
| Dockflow | |
| Dokeos S.P.R.L. | Walloon Brabant |
| Dom4J | Antwerp |
| Domatica | Flemish Brabant |
| Domeinnaam-registreren.net | Antwerp |
| Donna | |
| DPG Media Group N.V. | |
| DPO Network Europe | |
| DR Webdesign | West Flanders |
| Drawbotics | |
| Drink-IT | Flemish Brabant |
| Drive IT | |
| Droia Ventures | |
| Drone TechniXX S.P.R.L. | |
| Dropon | |
| Drupal | Antwerp |
| Dualyx N.V. | |
| Duo | West Flanders |
| Duoh! | East Flanders |
| Dust Mobile S.A./N.V. | |
| DVC S.A. | Brussels-Capital |
| DVK Hosting | Flemish Brabant |
| DX-Solutions | |
| Dynamic Software N.V. | Antwerp |
| DZTECH S.P.R.L. | Walloon Brabant |
| e-Health Venture Incubator | |
| E-LAC | Walloon Brabant |
| E-net Business | Namur |
| e-peas | |
| E-Spring Capital | |
| E.DSO | |
| E.R.I.M. S.A. | Walloon Brabant |
| e2e Solutions N.V. | East Flanders |
| EAGL | |
| EAI | |
| EASI S.A. | Walloon Brabant |
| easics N.V. | Flemish Brabant |
| Easy Concept | Hainaut |
| Easy For You | Flemish Brabant |
| Easyhost S.P.R.L. | East Flanders |