| Sixtrees | Singapore |
| Skuad | Singapore |
| Sky Movis | Singapore |
| Skycom Satellite Systems Pte Ltd | Singapore |
| Skydio | Singapore |
| Skyjuice Software | Singapore |
| Skylark | Singapore |
| Skylark Infotech Pte Ltd | Singapore |
| SkyMavis | Singapore |
| Slash | Singapore |
| Slasify | Singapore |
| Sleek Tech Pte Ltd | |
| SleekDigital, LLC | Singapore |
| SleekFlow | |
| SlidesAI | |
| SM Summit Holdings Ltd | Singapore |
| Smar Touch Technology Pte Ltd | Singapore |
| Smart Consulting | Singapore |
| Smart Nation Singapore | Singapore |
| Smart Ray Technologies Pte Ltd | Singapore |
| Smart Ship Hub | Singapore |
| Smart Source Technologies Pte Ltd | Singapore |
| SmartClean Technologies Pte Ltd | Singapore |
| SmartCode Solutions | Singapore |
| Smarten Spaces | Singapore |
| Smarter Me | Singapore |
| Smartflex Holdings Ltd | Singapore |
| Smartflex Technoloy Pte Ltd | Singapore |
| Smartkarma | |
| SmartMesh Foundation Pte Ltd | Singapore |
| SmartPeep | Singapore |
| SmartPesa | Singapore |
| SmartSpace Singapore | Singapore |
| SmsDome | Singapore |
| SMSExchange | Singapore |
| SODesires.com | Singapore |
| Soft-Pro Computer Pte Ltd | Singapore |
| Solar AI Technologies | Singapore |
| SoMin | Singapore |
| Sonm Pte Ltd | Singapore |
| Sony Electronics (Singapore) Pte Ltd | Singapore |
| Sopra Steria Singapore | Singapore |
| Sotirios Seridis | |
| Sound Paradigm Software Engineering Services Pvt Ltd | Singapore |
| SoundEye Pte Ltd | Singapore |
| Sourcegate Technologies Pte Ltd | Singapore |
| Sovereignwallet Network Pte Ltd | Singapore |
| SP SysNet | Singapore |
| SpaceAge Labs Pte Ltd | Singapore |
| Spaces Pte Ltd | |