| SecureIT-NET International Pte Ltd | Singapore |
| Securlogic Singapore Pte Ltd | Singapore |
| Selacorp | Singapore |
| SellerApp | Singapore |
| Sembcorp Industries Ltd | |
| Semiconductor Technologies Singapore | Singapore |
| SEMNet | Singapore |
| Semsusi Pte Ltd | |
| SensorFlow Pte Ltd | Singapore |
| Sensys Singapore Pte Ltd | Singapore |
| Sentient.io | Singapore |
| SEO Agency | |
| SEO Singapore Services | Singapore |
| SEOCompany.me | |
| SEOWorldClass | Singapore |
| Seratech | Singapore |
| Serial System Ltd | Singapore |
| Serpshake | |
| ServBridge Incorporated Pte Ltd | |
| Servo Dynamics Pte Ltd | Singapore |
| SESAMI (Singapore) Pte Ltd | Singapore |
| Seventh Sense AI | Singapore |
| SG Code Campus Pte Ltd | Singapore |
| SG Interactive | Singapore |
| SGHost | Singapore |
| SGInnovate | Singapore |
| Sharker Technology | |
| Sheetson | |
| Sherwin Anos | Singapore |
| Shield AI Technologies Pte Ltd | Singapore |
| Shiji Group | |
| Shinetown Telecom | Singapore |
| ShopBack | Singapore |
| Shopline Ltd | Singapore |
| Shopmatic Pte Ltd | Singapore |
| ShopOnline.com.sg | Singapore |
| SIACAD Pte Ltd | Singapore |
| Sift Analytics Group Pte Ltd | Singapore |
| Sigma.3 | Singapore |
| Sign | Singapore |
| Signetique IT Pte Ltd | Singapore |
| Signum Capital | Singapore |
| Silence Laboratories | |
| Silent Eight Pte Ltd | |
| Silent Frontier | |
| Silicon Box Pte Ltd | |
| Silicon Connection Pte Ltd | Singapore |
| Silk Systems Management Pte Ltd | Singapore |
| Silot Pte Ltd | Singapore |
| Silver Wings XR | |