| Stride Media | |
| Stride.VC, LLP | |
| Strident Computer Systems | Suffolk |
| Strikalite | Staffordshire |
| Strive Digital | |
| Strive Group | |
| Strolll | |
| Strongnet | Hampshire |
| StrongSoft Ltd | |
| Stroud Instruments Ltd | Gloucestershire |
| Structured Internet Ltd | Torfaen |
| Structured IT Solutions | Suffolk |
| Structured Software Systems Ltd | Cumbria |
| StructureFlow | |
| Struto | |
| Stryve | |
| STS Digital Ltd | |
| STS PC | Greater Manchester |
| Stuart Tyrrell Developments | Greater Manchester |
| stuartkerrs.com | |
| StudentStore | Suffolk |
| Studio 14 | |
| Studio 206 Ltd | |
| Studio 24 | Cambridgeshire |
| Studio 74 Creative Design | Somerset |
| Studio Contrast | |
| Studio Cotton Ltd | |
| Studio Create | Norfolk |
| Studio Folk Lore Ltd | |
| Studio Form Ltd | |
| Studio Gallant | |
| Studio Graphene | |
| Studio Link 11 | Essex |
| Studio Mindset | Belfast |
| Studio Mondate Ltd | |
| Studio Pepwuper Ltd | |
| Studio Renton | Nottinghamshire |
| Studio Republic | Hampshire |
| Studio Seventeen Ltd | |
| Studio Something | |
| Studio Spark | |
| Studio36Digital | Lancashire |
| Studio55 London | |
| StudioExcel Ltd | North Yorkshire |
| Studiomade | |
| StudioRav | West Midlands |
| StudioSpace | |
| Studiovine Ltd | |
| StudioWorx | |
| Studioyears | |