| Stemnovate Ltd | |
| Stenn International Ltd | |
| Step 2 Agility Ltd | |
| Stephen Coleclough | |
| Stephen Diehl | |
| Stephen Rowling | West Sussex |
| Sterling Pharma Solutions Ltd | |
| Sterling Savvy | |
| Sterling Solutions | |
| Stern Design | East Sussex |
| Steve Davis Graphic Design Ltd | |
| Steve Dawson | Lancashire |
| Steve Edson | |
| Steve Kemp | Glasgow |
| Steve Shaw Computer Services | |
| Steve Sims | |
| Steven Urmston | North Yorkshire |
| Stevenage Circuits Ltd | Hertfordshire |
| Stewart Investors | |
| Stewart Technology Ltd | Scottish Borders |
| STFC Business & Innovation | |
| Stickyeyes | West Yorkshire |
| Stiff Design | Warwickshire |
| Stilo | Wiltshire |
| Stilu Wen Solutions | Staffordshire |
| StimOxyGen | |
| Stinky Ink.com Ltd | Shropshire |
| Stinkyink.com | |
| Stirling IT Ltd | Stirling |
| Stirling IT Web Design | |
| STL Communications Ltd | Oxfordshire |
| STM Agency Ltd | |
| Stock Sourcing Wholesales Ltd | Essex |
| Stockall Electronics Ltd | |
| Stockport College | |
| Stockport Computers | Greater Manchester |
| Stocks Design | Leicestershire |
| Stok.ly | |
| Stoke Web Services | Staffordshire |
| Stone Group Ltd | Staffordshire |
| Stone Venture Partners Ltd | |
| Stoneridge | Dundee |
| Stop Go Networks Ltd | |
| Storacall Group | Surrey |
| Storacall Ltd | Gloucestershire |
| Store Valley | Suffolk |
| Storetec Services Ltd | |
| Storific | |
| Storm Consultancy (EU) Ltd | Somerset |
| Storm Internet Ltd | Oxfordshire |