| Supplyline Auto ID Ltd | West Sussex |
| Support To Perform | Belfast |
| SupportKey Ltd | Glasgow |
| Supportworks | Greater London |
| Supreme Creative Ltd | |
| Supreme Fintech | |
| Supreprof | |
| Sure Ltd | |
| Sure Valley Ventures | |
| Sure-Track Europe Ltd | Warwickshire |
| sureCore Ltd | |
| Surefire Print & Design | |
| Suretec Systems | Aberdeen |
| Surevine Ltd | |
| Surface Impression | |
| Surface Science Software Excellence | Kent |
| Surfboard Technology Ltd | |
| Surfing Penguin | |
| SurfOffice | |
| Surftec Ltd | Surrey |
| Surge | |
| Surge Rank | |
| Surges | |
| Surgical Dynamics Ltd | |
| SurgiNovi | |
| Surreal Vision Ltd | |
| SurrealDB Ltd | |
| Surrey NanoSystems Ltd | |
| Surrey Research Park | Surrey |
| Surrey Satellite Technology Ltd | Surrey |
| Survey Galaxy Ltd | |
| Sushi Venture Partners | Greater London |
| Sussex Community Internet Project | East Sussex |
| Sussex Designs | East Sussex |
| Sussex Mac Users' Group | East Sussex |
| Sussex PC Repair | East Sussex |
| Sussex Place Ventures Ltd | |
| Sussex SEO Ltd | East Sussex |
| Sussex Solutions | East Sussex |
| Sustainable Development Capital, LLP | |
| Sustainable Future Ventures Ltd | |
| Sustainable Network | |
| Sustainable Ventures | |
| Sustainable Web Solutions | Greater Manchester |
| Sutton Silver | |
| SV Health Investors, LLP | |
| SV-Marketing | |
| SVAIY ART | |
| Svek Computing Ktd | Gloucestershire |
| SVEK Computing Web Hosting | Carmarthenshire |