| Spica Media | |
| Spica Technologies Ltd | |
| Spicerack Media Ltd | |
| Spicy Pepper Ltd | |
| Spider Online | Glasgow |
| SpiderGroup | Bristol |
| Spiderscope Ltd | Leicestershire |
| Spidersnet | West Sussex |
| SpiderwebZ | Ards and North Down |
| SpiderWriting | Edinburgh |
| SpiderWriting SEO | Edinburgh |
| Spiderzone | |
| Spike Digital Ltd | |
| Spiky Hedgehog Web Design | Cheshire |
| SPIN Analytics | |
| Spin Ventures Ltd | Greater London |
| Spinbox Ltd | |
| Spindogs | Cardiff |
| Spine Agency | |
| Spink Telecom Consultants Ltd | |
| Spinning Clock Ltd | Nottinghamshire |
| Spinning Fox | |
| Spinview | |
| Spiral Media Ltd | Lincolnshire |
| Spiral Sites | Wiltshire |
| SpiralHosting Ltd | Belfast |
| Spire Digital | Wiltshire |
| Spire Hosting Ltd | Greater London |
| Spire Technology Ltd | Dorset |
| Spirea Ltd | |
| SPJ Marketing | South Yorkshire |
| Splash Damage Ltd | Greater London |
| Splashweb | Cambridgeshire |
| Splenify | |
| Splicecom | Hertfordshire |
| Splyt Technologies Ltd | |
| Spoke | |
| Spoko | |
| Sponge Group Holdings Ltd | |
| SporeGen Ltd | |
| Sport Tech Hub | Greater London |
| Sportech plc | |
| Sports Loft | Greater London |
| SportSoft (UK) Ltd | North Yorkshire |
| SPOS UK Ltd | |
| Spot Intelligence | |
| Spotbeam Communications | Essex |
| SpotDev Services Ltd | |
| Spotless Interactive | |
| Spotlight Studios Ltd | |