| Planetaweb | Mexico City |
| PlanetMedia | |
| Plataforma Abierta de Innovación | Mexico City |
| Play Business, S.A.P.I. de C.V. | |
| Plazanetwork | Mexico City |
| Pocket de Latinoamérica, S.A.P.I. de C.V. | Mexico City |
| PoderNet | Mexico City |
| Polígono Capital | Jalisco |
| Posiciona.Digital | |
| Power Testing de México | |
| PPS Tecnologia | |
| Pragmatec | |
| Praxis | Mexico City |
| Preparatoria CUAM | |
| Prexto Financial, S.A.P.I. de C.V. | |
| Productos Soluciones y Servicio, S.A. de C.V. | Mexico City |
| Programatica Creativa | Mexico City |
| Promecap, S.A. de C.V. | Mexico City |
| Promotech México, S.A. de C.V. | Mexico City |
| Promoweb | Mexico City |
| ProTecnia | Mexico City |
| Proveedores de Facturación Electrónica y Software, S.A. de C.V. | State of Mexico |
| Proyecto:pixel | Mexico City |
| Proyectos y Conferencias S.A. de C.V. | Mexico City |
| Publi-K2 | Mexico City |
| Publicidad Guadalajara | |
| Publico | Mexico City |
| Publisearch, S.A de C.V. | |
| Publitotal | Nuevo León |
| PUNK Solutions, S.A. de C.V. | Quintana Roo |
| Punto & Chroma | |
| Punto Blu | Mexico City |
| Punto Commerce | Jalisco |
| Punto Coworking | Mexico City |
| Puntoasterisco | |
| PureChart | |
| PV Comunicaciones, S.A. de C.V. | Chihuahua |
| PWebCast | |
| PYME One | |
| PYV Tecnologia | Mexico City |
| Q Marketing Internet | |
| Q-Soft México, S.A. de C.V. | Chihuahua |
| Qbit Mexhico | Mexico City |
| Quadrantix | Baja California |
| Quadrato | Mexico City |
| Qualitrain | Mexico City |
| Quality & Knowledge on IT Services, S.A. de C.V. | |
| Qualtec | Mexico City |
| Qualtop | |
| Quanticus | Querétaro |