| Rockbrook Engineering Ltd | Dublin City Council |
| Rockfield Medical Devices | |
| Rocudo | Galway City Council |
| Roll'n'Code | |
| Ronnie Moore Ltd | Cork City Council |
| Ronspot Ltd | |
| Roomex | |
| Royal College of Physicians of Ireland | |
| Royal College of Surgeons in Ireland | |
| RSMLive | Dublin City Council |
| RTsafe | |
| Rubicon Centre | Cork City Council |
| Ryco Web Ltd | |
| Saadian Technologies | Dublin City Council |
| SaaStock | Dublin City Council |
| Sabrina Dent | Cork City Council |
| Safer-Networking Ltd | Wicklow County Council |
| Salaso Health Solutions | Limerick City and County Council |
| Sallynoggin College | |
| Salmon Software Ltd | Dublin City Council |
| Salmon Technologies | |
| Salt Marketing | |
| Sam Ferguson Design | |
| Scurri | Wexford County Council |
| Seabased | |
| Seabrook Research Ltd | Cork City Council |
| Seapoint Finance Ltd | |
| SearchStudio | Dublin City Council |
| Secora Consulting Ltd | |
| Secure Computing Forum | |
| Sedicii Innovations Ltd | |
| Seditio Group | |
| Seed Technology Ltd | |
| Seek Internet Solutions Ltd | Cork City Council |
| Select Technology Sales and Distribution Ltd | Dublin City Council |
| Senpai IT Solutions | Dublin City Council |
| Sensorpro | Limerick City and County Council |
| SEO & Grow | |
| SEO Consultant Ireland | Dublin City Council |
| SEO Pod Ireland | Dublin City Council |
| SEOPLAN.CO | |
| SEOSolutions.ie | |
| SEOWIZARD | |
| SeqBiome | |
| Serenity Dojo | |
| Seroba Life Sciences | |
| Serosep Ltd | |
| Share IT Ltd | |
| Shareline | |
| Shercom Ltd | Carlow County Council |