| Spendways | |
| SPGL InformatiK | Loire-Atlantique |
| Sphere Informatique | Gironde |
| SPHEREA | |
| Sphinx Manager | Bouches-du-Rhône |
| Spiders | Paris |
| SPIE ICS | Hauts-de-Seine |
| Spigao | Haute-Garonne |
| Spigraph France S.A.S. | Isère |
| SpikImm | |
| Spindata | Yvelines |
| SpineGuard S.A. | |
| SpinFire | Gironde |
| Spintec | |
| Spirea | |
| Spirica | |
| Splash Internet | Tarn |
| Splio | Paris |
| SPOKE | |
| SPooN | |
| Spore.Bio | |
| SportEasy S.A.S. | |
| Sportheroes | Paris |
| SPOT MY WEB | |
| Spotlight Medical | |
| Sprintvision | Val-d'Oise |
| SPV Informatique | Bas-Rhin |
| SQI IT Solutions | Yvelines |
| SQLI | Hauts-de-Seine |
| SQLiteManager | Paris |
| Squad | |
| Squall Network | Vienne |
| Squardata | |
| Square Partners | Pyrénées-Orientales |
| Squey | |
| Squirrel S.A.S. | |
| Sqwad | |
| SRCI | |
| SRD | Nord |
| SRI International Sarnoff | |
| SS2i Services | Charente-Maritime |
| ST-Telecoms | Yvelines |
| Stabler Technologies S.A.S. | |
| Stackr | Ain |
| STAE Toulouse | Haute-Garonne |
| StaffMe | |
| Stage11 S.A.S. | |
| Stago | |
| Stampyt S.A.S. | Loire-Atlantique |
| StandOut France | |