| SOPHiA GENETICS S.A. | |
| Sopra HR | |
| Sopra Steria Group | |
| Soprotocol | |
| Sorbonne Université | Paris |
| Sorbonne Université - Institut Systèmes Intelligents et de Robotique | |
| Sorbonne Université - Quantum information center | Paris |
| Sorecson | Métropole de Lyon |
| SORELEC | Ille-et-Vilaine |
| SOS 02 Informatique | Aisne |
| SOS Dépannage Informatique | Val-de-Marne |
| SOS Dépanne PC | Finistère |
| Sos Fichiers | Hauts-de-Seine |
| SOS Informatique | Bouches-du-Rhône |
| SOS Mac S.A.R.L. | Seine-et-Marne |
| SOS Marne Informatique | Marne |
| SOS PC 35 | Ille-et-Vilaine |
| SOS-Data | Vienne |
| Sosdonnees | Paris |
| SOTIEG | |
| Sotratech | |
| SOUBABERE Informatique | Gironde |
| Soubeyrand Consultant | Bouches-du-Rhône |
| Source | Seine-Saint-Denis |
| Source Ventures | |
| Souris Kiclic | Allier |
| Sous-titre Webdesign | Paris |
| South Champagne Business School | |
| Southcomp Polaris | Val-de-Marne |
| Sowefund S.A.S. | |
| SOWIT | |
| SP2i | Essonne |
| Space Aeronautic Technologies | |
| Space Designer 3D | |
| SpaceFill | Paris |
| SpaceLocker S.A.S. | |
| SpaceSense | |
| Spallian | Paris |
| SparingVision | |
| Spark Cleantech | |
| SPARKK | |
| Sparklane | Paris |
| Sparkup | |
| Spartel | |
| Spatialist | |
| Specinov | Maine-et-Loire |
| Spedding Research Solutions S.A.S. | |
| Speechi | Nord |
| Speeral | Gard |
| Spendesk | Paris |