| DOS Software, S.A. | Barcelona |
| Dost | Barcelona |
| DOVALO Informática | Las Palmas |
| Dozen Investments PFP, S.L. | Barcelona |
| DPIProducts, S.L.U. | Madrid |
| DQ System, S.L. | Madrid |
| Dracnet Projects | Barcelona |
| DraperB1 | Valencia |
| Dreamsite | Madrid |
| Dribba Development & Consulting, S.L. | Barcelona |
| Drive REVEL, S.L. | Madrid |
| DropCatch Domains | |
| DS Data Systems Iberia, S.A. | Madrid |
| DSTnet TPV | Cádiz |
| Duacode | A Coruña |
| Duero Imagen | Burgos |
| Duocom Europe, S.L. | Las Palmas |
| Dusnic | Valencia |
| Dygicom | Tarragona |
| Dyna Tech | Barcelona |
| Dynamo.Video | Barcelona |
| E-creasolutions | Madrid |
| E-FinanceClick | |
| e-LAND Soluciones Digitales | |
| e-NetBlue | Madrid |
| E-nvía | Barcelona |
| e-SORT | Madrid |
| E3 Consultores Informáticos | Valencia |
| E8d Soluciones | |
| EAcom Systems, S.L. | Madrid |
| EADA Business School | Barcelona |
| EADE - Estudios Universitarios | |
| EADe comunicació | Lleida |
| EAE Business School | |
| EALDE Business School | |
| Ealyx | |
| Earcon, S.L. | Barcelona |
| Easo Ventures | Gipuzkoa |
| Easy Code | A Coruña |
| EasyVoIP | Santa Cruz de Tenerife |
| Eccocar Sharing, S.L. | Madrid |
| Eccuo | |
| ECIJA | Madrid |
| Ecinsa | Madrid |
| Eclickse Digital, S.L. | Biscay |
| Eclom Services | Madrid |
| Ecna Informática, S.L. | Biscay |
| Ecocomputer, S.L. | Asturias |
| Ecom Telecomunicaciones | Valencia |
| Ecomspain Conectividad, S.L. | Madrid |