| SOS Info Tech | |
| SOS Ordi Montréal | Quebec |
| SOS Phone | Quebec |
| SOSCIP | Ontario |
| SosEncre.com | Quebec |
| Soshell Digital | |
| Sosido | |
| Sotca, Inc. | Ontario |
| SOTI, Inc. | Ontario |
| Sotique, Inc. | Ontario |
| SotoNets Cloud Solutions | |
| Soulfx Technologies, Inc. | Ontario |
| Soulpepper | British Columbia |
| Sound Blade Medical | |
| Sound Foundation | Ontario |
| Sound Software | Ontario |
| Soundafex | |
| SoundBite Medical Solutions | |
| Souqh Technologies, Inc. | |
| Source Atlantic Ltd | |
| Source Cable Ltd | Ontario |
| Source Code Staffing | Ontario |
| Source From Ontario | |
| SourceDesk | |
| SourceKnowledge | |
| SourcePoint Business Group | |
| Sources | |
| Sourcevolution | Quebec |
| Souritech Informatique, Inc. | Quebec |
| Sous-traitance industrielle Québec | |
| South Huron Office Solutions | Ontario |
| South Island Prosperity Partnership | |
| South-Alta Communications, Inc. | Alberta |
| Southampton Microcomputers, Inc. | |
| Southeast College | |
| Southeast TechHub | |
| Southeastern Computer Solutions | Saskatchewan |
| Southeastern Telecommunication Services | Ontario |
| Southern Alberta Institute of Technology | Alberta |
| Southern Alberta Institute of Technology - Bachelor of Applied Technology Geographic Information Systems | Alberta |
| Southern Alberta Technology Council | Alberta |
| Southern East, Inc. | |
| Southpaw Technology | Ontario |
| Southwestern Ontario Angel Group | Ontario |
| Southwind Software Training & Consulting Ltd | Alberta |
| Soutien Informatique Rive-Sud | |
| SOVAR | Quebec |
| SozenTech | Alberta |
| Sozo Media | |
| Space Canada | |