| MERAK Systems Corporation | Ontario |
| Merang TravelOffice | Ontario |
| MercAssist | Quebec |
| Merced Media | Ontario |
| Merchant Accounts.ca | Ontario |
| Merchant Applications, Inc. | Ontario |
| Merchant Corner | Quebec |
| Merchant Services, Inc. | Ontario |
| Merck Canada, Inc. | |
| Mercure Conseil | |
| Mercury Grove, Inc. | Ontario |
| Mercury Technology Services | British Columbia |
| Merge Solutions, Inc. | Ontario |
| Mergen Digital | |
| Mérici Collégial Privé | |
| Meridia Recruitment Solutions | Nova Scotia |
| Meridian Techical Services | |
| Meridian Technical Services | |
| Meridian4, Inc. | Quebec |
| Meridien | Quebec |
| Merinio | Quebec |
| Merinov | |
| Merisia | |
| Merit Solutions, Inc. | Ontario |
| Merit-Trax Technologies, Inc. | Quebec |
| Meritek | Quebec |
| Merix Technologies | Quebec |
| Merkur | |
| Merlinus Software Solutions | British Columbia |
| MES Hybrid Document Systems | Ontario |
| Mes Livres Comptables | |
| Mesbois, Inc. | Quebec |
| Mesentech | |
| Mesh | Ontario |
| MESH Diversity | |
| MESH Insights | |
| Mesh Networks | Ontario |
| Meshmatic | |
| Meshroad Marketing | |
| Mesotec | |
| Messa Consulting | Ontario |
| Message Impact Systems, Inc. | British Columbia |
| Messagepoint, Inc. | Ontario |
| Messageware, Inc. | Ontario |
| MET – Aéroport métropolitain de Montréal | |
| Meta Materials, Inc. | |
| Meta Scope | |
| Meta Strategies | Ontario |
| Meta4 Interactive, Inc. | Quebec |
| MetaCrawl | |