| MediaSpark, Inc. | Nova Scotia |
| Mediaspawn | Ontario |
| MEDIASUN.ca | Quebec |
| MediaTile | Ontario |
| MediaTown Marketing | Ontario |
| MediaTransact | |
| MediaValet | |
| Mediavanta | Ontario |
| MediaVice Machine & Web | Ontario |
| MEDIAVORE Interactif | Quebec |
| Mediaweb, Inc. | Quebec |
| MediaZone+ | Quebec |
| Medical Innovation Xchange | |
| Medical Resources Management | Ontario |
| Médicament Québec | |
| Medicine Hat College | |
| Mediclaim | British Columbia |
| Medicure, Inc. | |
| Medicuro | |
| MediLumine, Inc. | |
| Medimap | |
| Medinet | British Columbia |
| Mediphage Bioceuticals, Inc. | |
| Medirex Systems, Inc. | Ontario |
| Médisolution | Quebec |
| Meditrain | |
| Mediumcube | Ontario |
| Mediumrare | Alberta |
| Medley Haus | |
| Medly | |
| MeDM, Inc. | |
| MedMe Health | |
| MedMira, Inc. | |
| MEDO.ai | Alberta |
| Medora Solutions, Inc. | British Columbia |
| Medreddie, Inc. | |
| Medrox | |
| Medscint | |
| MedStack, Inc. | Ontario |
| Medtech Canada | Ontario |
| Medtel Software Ltd | Ontario |
| MEDTEQ+ | Quebec |
| Medunik Canada | |
| Medwave Optique, Inc. | Quebec |
| Meetingmax | |
| Meevo Digital | |
| Mega Computer Systems | Ontario |
| Méga Info Systèmes | Quebec |
| Mega PC | Quebec |
| Mégaburo | Quebec |