| Burst Digital | |
| Busii | Western Cape |
| Business Engage | |
| Business Engineering (Pty) Ltd | Gauteng |
| Business Optimization Training Institute | |
| Business Process Enabling South Africa | |
| BustQue | Gauteng |
| BVI Network Security Services (Pty) Ltd | Gauteng |
| Bweb (Pty) Ltd | |
| Bydrae (Pty) Ltd | Western Cape |
| Byte Orbit | Western Cape |
| Bytespark | Western Cape |
| C-Boards | Gauteng |
| C-Page | Gauteng |
| C2I2 Systems | Western Cape |
| C2KIT Computer Supplies (Pty) Ltd | |
| Cable Applications | Gauteng |
| CaCell | Gauteng |
| CAD Corporation | Gauteng |
| CAD4All Software CC | Western Cape |
| Cagro Consulting Services | Gauteng |
| Camara Consulting | Western Cape |
| Camelot International | |
| Cameraman CCTV | Gauteng |
| Camsoft Solutions | Western Cape |
| Canon South Africa (Pty) Ltd | Gauteng |
| Cantaloupe Digital | Gauteng |
| Cape Biologix | |
| Cape Business Online | |
| Cape Health Tech Week | Western Cape |
| Cape Higher Education Consortium | Western Cape |
| Cape Innovation & Technology Initiative | Western Cape |
| Cape Peninsula University of Technology | Western Cape |
| Cape Peninsula University of Technology - Informatics and Design | Western Cape |
| CapeConnectInternet | Western Cape |
| CapeSoft | Western Cape |
| CapeTel | Western Cape |
| CapeWeb | Western Cape |
| Capital Appreciation Ltd | |
| Capital Design | Gauteng |
| Capital Eye Investments (Pty) Ltd | Gauteng |
| Capitalize Digital (Pty) Ltd | Western Cape |
| Cardinal (Pty) Ltd | |
| CardScan | |
| Carry1st | Western Cape |
| Carscan | |
| Cartmell & Cartmell Communications (Pty) Ltd | |
| Cartridge Hyper | Gauteng |
| Cartridge Warehouse | Gauteng |
| Cartrige World | Western Cape |