| Intelligent Web | KwaZulu-Natal |
| IntelliStor | Gauteng |
| IntelTech (Pty) Ltd | Western Cape |
| Intense Broadband | Western Cape |
| Inter Flare (Pty) Ltd | |
| Interactive Systems Designs | Gauteng |
| Intercode Payroll | Gauteng |
| Interconnect Systems | Gauteng |
| InterDev Systems | Western Cape |
| International Trade Institute of Southern Africa | |
| Internet Rankings and Search Engine Optimization | Gauteng |
| Interon | Gauteng |
| InterWeb SA | Western Cape |
| Inteto Connect | Gauteng |
| inTouchLink | Gauteng |
| Intoweb | Gauteng |
| Intratec Data Recovery | KwaZulu-Natal |
| Intratec Digital | Western Cape |
| Introstat | Gauteng |
| Intuitive Connections | Western Cape |
| Investoreports | Gauteng |
| InvestSure | |
| InvoTech Innovation Business Incubator | KwaZulu-Natal |
| Io Media Agency | |
| IoT.nxt | Gauteng |
| IP Dimension | Gauteng |
| iPay (Pty) Ltd | Western Cape |
| iPortals (Pty) Ltd | Gauteng |
| iQ Retail | Western Cape |
| IQData | Gauteng |
| ISA Carstens Academy | |
| ISAT | Eastern Cape |
| Isenzo | Western Cape |
| iSimon Website Design and Web Development | Western Cape |
| Isizwe | Western Cape |
| ISN Managed Services (Pty) Ltd | Western Cape |
| iSolv Technologies | Gauteng |
| iSolve Business Solutions | Gauteng |
| iSolve Business Solutions (Pty) Ltd | |
| ISPDATA | Gauteng |
| IT Box Computer Services | Western Cape |
| IT Corporation | KwaZulu-Natal |
| IT Design | Eastern Cape |
| IT Giant Web | Western Cape |
| IT Guy South Africa | |
| IT Naledi Solutions | Western Cape |
| IT News Africa | Gauteng |
| IT People | Gauteng |
| IT Squared | Gauteng |
| IT-Online | Gauteng |