| I.R. Pope & Sons (Pty) Ltd | Western Cape |
| i1Solutions | Western Cape |
| i22 Digital Agency | |
| I3 Zone Development | Western Cape |
| iAdapt | Gauteng |
| Ianko's gis page | Gauteng |
| iBanza | Western Cape |
| IBIS Consulting | Gauteng |
| IBIS Technology (Pty) Ltd | Western Cape |
| ICESA City Campus (Pty) Ltd | |
| Iclix | Free State |
| Icon Era | Eastern Cape |
| iConnect SA | Gauteng |
| iConnection | Gauteng |
| iCreations | Gauteng |
| Idea Camp | Western Cape |
| Idea Power | Gauteng |
| Idea-Catalyst | Western Cape |
| IdeaNav | |
| Ideco Group Ltd | Gauteng |
| Ideers Media | |
| Identity Studios | |
| iDigiSol Web | |
| IDoWebsites | |
| iDS Hosting | Western Cape |
| IDS Secure | Western Cape |
| IDTS | |
| IDU | Western Cape |
| IEDM Digital Marketing | Gauteng |
| IEWC | Gauteng |
| iFactor | Gauteng |
| Ignite Media | |
| IGrow Digital | |
| IIE MSA | |
| IIS Group | Western Cape |
| iKabot | Western Cape |
| iKhokha | KwaZulu-Natal |
| iLead Online | Gauteng |
| iLearn | Gauteng |
| iLembe Technologies | KwaZulu-Natal |
| iLite | Western Cape |
| Ilogic | |
| Imafin | |
| Imagine ISP | Gauteng |
| IMM Graduate School | |
| Impact Amplifier | |
| Imperative Technology | Gauteng |
| Imperial Logistics | |
| Impero Consulting | Gauteng |
| Impression Management | KwaZulu-Natal |