| Smart Dubai | Dubai |
| Smart IT Solutions L.L.C. | Abu Dhabi |
| Smart Navigation Systems | Abu Dhabi |
| Smart Prestige Technology Solutions | Abu Dhabi |
| Smart Security U.A.E. | Sharjah |
| Smart World Computer Trading | Dubai |
| SmartClick.ae | Dubai |
| Soar PR | |
| Social Bubbles It Services | |
| SocialCTR | |
| Socialize | Dubai |
| Socio | |
| Soft Tech | |
| Soft Valley | |
| Softeko Edge | |
| Softmedia Dubai | Dubai |
| SoftnSolve Software Development Company | |
| Software-Planet.com | Sharjah |
| Soldius AI Tech Ltd | |
| SolidWebBase.com | Dubai |
| Solutions Middle East | Dubai |
| Sony Middle East and Africa FZE | Dubai |
| Sorbonne University Abu Dhabi | |
| SoulWallet | Dubai |
| Soup Group FZ LLE | Dubai |
| Sowaan ERP | |
| Space Imaging Middle East | |
| SpaceTo | |
| Span Group | Dubai |
| Spell Systems | |
| Sphinx Mind | |
| Spider Designers FZE | |
| Spiderz | Dubai |
| Sprint Co Web | |
| Sprint Marketing & Technology | |
| SSTech | Sharjah |
| Stake Properties Ltd | Dubai |
| Staq Technologies Ltd | |
| Starkflow | |
| Start Tech | |
| Stimulus Web Design | Dubai |
| STME | Dubai |
| STON.fi | Dubai |
| StorIT | Dubai |
| Stornest Solutions Ltd | Abu Dhabi |
| Stratign | Dubai |
| Strawberry Labs | |
| StruqtIO | |
| Studio3 FZE | |
| Study World Group | |