| Softech.pk | Punjab |
| Softgear | |
| SoftHof (Pvt) Ltd | Punjab |
| Softrack Technologies | Sindh |
| Softronix (Pvt) Ltd | Punjab |
| Softsunrise Software House and Training Center | |
| Software Alliance | |
| Software Channel (Pvt) Ltd | Sindh |
| Software Island | Sindh |
| SoftwareHub | |
| Softwares.com.pk | Punjab |
| SoftWorld | Sindh |
| Solution Developers | |
| Solutions Player Ltd | Islamabad Capital Territory |
| Solutionsware | Punjab |
| SONEXT | |
| SourceCode | |
| Spadasoft (Pvt) Ltd | |
| Sparkleo | |
| SpellWeb Design | Sindh |
| SprintOps | |
| Sprintstart | |
| SR Digital | |
| St. Joseph's College for Women | |
| StackExpert (Pvt) Ltd | |
| StackWeavers Pvt Ltd | |
| Stallion Publishers | Islamabad Capital Territory |
| Starlite Software Technologies | |
| Startups Pakistan | Sindh |
| Steam Concepts | Sindh |
| Stellar Technologies | |
| Strategic Reach Marketing | |
| Strativ | |
| Suave Solutions | Punjab |
| Sukkur IAB University | |
| Sulata iSoft | Punjab |
| Superb Developer | |
| Superior University | |
| Supernet Ltd | Sindh |
| SuperNova | Sindh |
| Supersoft Technologies | Sindh |
| SW3 Solutions | Punjab |
| Swaam | |
| Symbios.pk | Sindh |
| Symits | Sindh |
| Symmetry Group | Sindh |
| SympleLogix | |
| Sync Clouds | |
| Sync4Tech | |
| SynchTech Solutions | |