| Shah Themes | |
| Shaheed Benazir Bhutto City University, Karachi | |
| Shaheed Benazir Bhutto Dewan University | |
| Shaheed Benazir Bhutto University, Shaheed Benazirabad | |
| Shaheed Benazir Bhutto University, Sheringal | |
| Shaheed Benazir Bhutto Women University | |
| Shaheed Mohtarma Benazir Bhutto Medical University Larkana | |
| Shaheed Zulfikar Ali Bhutto Law College | |
| Shaikh Khalifa Bin Zayed Al Nahyan Medical & Dental College | |
| Shalamar Medical and Dental College | |
| Shaukat Khanum Memorial Trust | |
| SheDev | |
| ShehzadOnline | |
| Sheikh Zayed Medical College Rahim Yar Khan | |
| Shifa Tameer-e-Millat University | |
| Shinersoft | Sindh |
| Shopistan | Punjab |
| Shoutifyme | Punjab |
| Sibisoft | |
| Sidat Hyder | Islamabad Capital Territory |
| Sigi Technologies | |
| SigmaTec Solutions | Punjab |
| Silicon Technologies | Sindh |
| SIMSIN Edtech Pvt Ltd | |
| SIMSIN Edtech Pvt Ltd | |
| Sindh Agriculture University, Tandojam | |
| Sindh Madressatul Islam University | |
| Sir Adamjee Institute of Management Sciences | |
| Sir Syed CASE Institute of Technology University | |
| Sir Syed College of Medical Sciences for Girls | |
| Sir Syed University of Engineering & Technology | |
| Sir Syed University of Engineering and Technology | Sindh |
| Skpsoft (Pvt) Ltd | Punjab |
| Skylinx Technologies | Punjab |
| SkySoft Connections | |
| SkySphere (Pvt) Ltd | |
| Smartfun Studios (Pvt) Ltd | |
| SMI Soft Tech | |
| SMSAPP | Islamabad Capital Territory |
| SocialPie Technologies | |
| Sofcom (Pvt) Ltd | Sindh |
| Sofizar | Punjab |
| Soft Enterprise | |
| Soft Pyramid | Punjab |
| Soft Solutions Pakistan | Punjab |
| SoftandHost | |
| SOFTEC, the Software Exhibition and Competition | Punjab |
| Softech Business Services Ltd | |
| Softech Microsystems | Sindh |
| Softech Systems | Punjab |