| Soft-Logic | |
| Soft-Portable | Moscow |
| Soft-portal | Moscow |
| Soft-Release | Moscow |
| Soft-Servis | Moscow |
| Softaccess | Moscow |
| Softage | Novosibirsk |
| SoftBcom | Moscow |
| SoftDevelop | Moscow |
| Softerium | Moscow |
| SoftExpert | Moscow |
| Softgrad | Rostov |
| SoftHome | Moscow |
| SoftLab-NSK Co. Ltd | Novosibirsk |
| Softline | Moscow |
| Softline Venture Partners | Moscow |
| Softmart | Moscow |
| SoftMasters | |
| Softnew.ru | Moscow |
| Softodrom.ru | Moscow |
| Softopark | Moscow |
| SoftOrbits | |
| SoftOut | Moscow |
| SoftPortal.com | Moscow |
| SoftRing | Moscow |
| softRU.ru | Moscow |
| SoftTime | Moscow |
| Softun | Moscow |
| Software Inc., Company | Moscow |
| Software Russia | Moscow |
| Softway.ru | Moscow |
| Soil Science Institute named after V.V. Dokuchaev | |
| Sonda Technologies | Chelyabinsk |
| Sostav | Moscow |
| Sota Shop | Moscow |
| Sotel | Moscow |
| South Ural State University | |
| Southern Federal University | Rostov |
| SOVA | |
| Sowsoft | Kirov |
| Space Research Institute of the Russian Academy of Sciences | |
| Space XY | |
| SpaceWeb LLC | Moscow |
| Spark.ru | |
| SPC «KRUG» | |
| Spech Analytics | |
| Spice IT Recruitment | Moscow |
| Spider Project | Moscow |
| SQLLY Development | Moscow |
| SR Space | |