| Crobox | |
| Crodeon Technologies B.V. | |
| Crooijmans ICT B.V. | North Brabant |
| Cross Communications | |
| Cross Point | Drenthe |
| Crossbeta Biosciences B.V. | |
| Crossfire Oncology B.V. | |
| Crosspring B.V. | |
| Crownstone | |
| Crunchr | North Holland |
| Crystal Blockchain Analytics | North Holland |
| Crystal Cable | Gelderland |
| CS Net | South Holland |
| CSH Automatisering | |
| CSIRT.Global | |
| CSl-HSI Automatisering | Overijssel |
| CSN B.V. | Overijssel |
| CSN Groep B.V. | Utrecht |
| CSRJobs | |
| CTB | Gelderland |
| Cube | |
| CubeWorks B.V. | |
| Culgi B.V. | South Holland |
| CultureSuite | |
| Cupenya Solutions B.V. | |
| Cupo | Utrecht |
| CURO Payments B.V. | |
| Custom Connect | |
| CV Compiler | North Holland |
| CVC DIF | |
| CWORX | North Brabant |
| Cyan Reef B.V. | |
| Cyber Capital | |
| Cyber Cloud B.V. | |
| Cyber Defensie Nederland | Overijssel |
| CyberServ B.V. | |
| Cybmermedia Television B.V. | |
| Cycling Bear Studio | |
| CycloMedia Technology B.V. | Gelderland |
| Cyclomics | |
| Cyclomics B.V. | |
| CyTuVax B.V. | |
| D Sens Learning | North Holland |
| D+S Software | South Holland |
| d-Media web professionals | North Brabant |
| Da Vinci International B.V. | Gelderland |
| Da Vinci Laboratory Solutions B.V. | |
| Daadkracht | Gelderland |
| DAB.bio, Inc. | |
| Daib | |