| Mazelbolt | Tel Aviv District |
| McCann Digital | |
| MCE Systems Ltd | Tel Aviv District |
| Mckit Systems | Central District |
| Medasense Biometrics Ltd | Tel Aviv District |
| Medatech Ltd | Haifa District |
| MedAware | Central District |
| medCPU | Tel Aviv District |
| Medic Vision | |
| MediGus | |
| Medinol | Tel Aviv District |
| Medisim | |
| Medistat | Tel Aviv District |
| Meditec | |
| MediWound | |
| MediWound Ltd | Central District |
| Medoc | |
| MedOne | Central District |
| MEDX Xelerator | Tel Aviv District |
| Meet.Capital | Tel Aviv District |
| Mega Fabs | |
| Megatone Systems & Technologies Ltd | Tel Aviv District |
| Meitavsys | Tel Aviv District |
| Mekashron | Central District |
| Melcap Systems | Haifa District |
| Melingo | Tel Aviv District |
| Memcyco Ltd | Tel Aviv District |
| MeMed Ltd | Haifa District |
| Mentee Robotics | |
| Mer Telemanagement Solutions Ltd | Central District |
| Mercury Software Ltd | Tel Aviv District |
| Meron Capital | Tel Aviv District |
| Meron Capital | |
| Mesh Security Ltd | Tel Aviv District |
| Meshy Software | Tel Aviv District |
| Metafora | Tel Aviv District |
| MetalGrass | Tel Aviv District |
| Metaphor Vision Ltd | Central District |
| MetaSight Diagnostics | Central District |
| Meteorit | Central District |
| Metrolight Ltd | Central District |
| MetroLink | Tel Aviv District |
| Metropolis Digital | |
| Metzag Imaging Systems Ltd | Tel Aviv District |
| Microdel Ltd | Central District |
| MicroKim | |
| MicroKim Ltd | Haifa District |
| Microline Computers & Software Ltd | Tel Aviv District |
| Micronet Ltd | Tel Aviv District |
| Micropay | Tel Aviv District |