| SATT PACA Corse S.A.S. | |
| SATT Paris-Saclay | |
| SauveGarde.fr | Val-de-Marne |
| Save Group | |
| Savsoft | Hauts-de-Seine |
| SAY Digital | |
| Saycurit | |
| Sayse | |
| SB Technologies | Paris |
| sb-Peptide | |
| SB2I | Rhône |
| SBE S.A.S. | Paris |
| SBII | Loire-Atlantique |
| SBInformatique | Hautes-Alpes |
| SC Informatique | Haute-Savoie |
| Scalair | |
| Scaleflex | |
| Scalerize | |
| Scaleway | Paris |
| Scalian | Haute-Garonne |
| Scalingo S.A.S. | |
| Scalinx | |
| SCALINX | |
| Scandrone | |
| Scarcell Therapeutics | |
| SCEL | Essonne |
| Scénario Informatique Conseil | Paris |
| Scénario Interactif | Haute-Garonne |
| Schaeffer Productique | Haut-Rhin |
| Schneider Electric | |
| SchoolMouv | |
| SCIAM | |
| Scidot | Paris |
| Science & Vie | |
| Sciences Po | |
| Sciences Po Lille | |
| Sciforma | Paris |
| Scilab | Val-de-Marne |
| SCINTIL Photonics | |
| Scipio Bioscience | |
| SCJ Informatique | Seine-Maritime |
| SCOP Gassagosso | |
| ScoQi | Seine-Maritime |
| Score & Secure Payment | |
| Score'n'co | |
| Scorvitech S.A.R.L. | Morbihan |
| ScrapingBee | |
| Scrapster | |
| Screenpresso | Haute-Garonne |
| Screenreach Interactive France S.A.S. | |